|
rs9366816
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
|
24940741 |
2014 |
|
rs9366816
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
|
24940741 |
2014 |
|
rs9287655
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic variation in FCER1A predicts peginterferon alfa-2a-induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B.
|
30972912 |
2019 |
|
rs9277542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542).
|
22737229 |
2012 |
|
rs9277535
|
|
G |
0.760 |
GeneticVariation |
GWASCAT |
A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
|
24940741 |
2014 |
|
rs9277535
|
|
A |
0.760 |
GeneticVariation |
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents.
|
28119119 |
2017 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance.
|
24846544 |
2014 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population.
|
21408128 |
2011 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population.
|
28613373 |
2017 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B.
|
21346778 |
2011 |
|
rs9276370
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
|
24940741 |
2014 |
|
rs9275572
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two recent genome-wide studies showed that the single-nucleotide polymorphisms in the HLA-DQ region (rs2856718 and rs9275572) were associated with chronic hepatitis B virus infection and chronic hepatitis C virus-associated hepatocellular carcinoma in Japanese patients.
|
24750255 |
2014 |
|
rs9275319
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to determine impacts of HLA-DQ polymorphisms and their interactions with HBV mutations on the risks of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). rs2856718 (A>G) and rs9275319 (A>G) were genotyped in 1342 healthy controls, 327 HBV surface antigen (HBsAg) seroclearance subjects, 611 asymptomatic HBsAg carriers (ASCs), 1144 chronic hepatitis B (CHB) patients, 734 LC patients, and 1531 HCC patients using quantitative PCR.
|
25281206 |
2014 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study investigated the influence of combined p53 Arg72Pro and MDM2 SNP309 on the risk of developing HCC in patients with chronic hepatitis B virus infection, and evaluated the significance of the two combined SNPs on patient prognosis.
|
23292895 |
2013 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Fifty-eight patients with chronic hepatitis B and 30 healthy individuals were genotyped in terms of the p53 gene codon 72 Arg72Pro polymorphism by PCR-RFLP.
|
22892830 |
2012 |
|
rs8099917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we aimed to evaluate the effect of two single nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) (rs12979860C/T and rs8099917G/T) on chronic hepatitis B virus (CHB) infection in Thai population.
|
25664396 |
2015 |
|
rs78900671
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide Association Study Identifies Genetic Variants Associated With Early and Sustained Response to (Pegylated) Interferon in Chronic Hepatitis B Patients: The GIANT-B Study.
|
30715261 |
2019 |
|
rs7813
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the relationship between three SNPs (rs3757 in DGCR8, rs636832 in AGO1, rs7813 in GEMIN4) in miRNA-machinery genes and chronic hepatitis B, we genotyped the SNPs by high resolution melting method (HRM) in a case-control study of 332 unrelated chronic hepatitis B patients and 352 unrelated healthy controls in Western China.
|
25239527 |
2014 |
|
rs7756516
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
|
24940741 |
2014 |
|
rs7712322
|
|
|
0.010 |
GeneticVariation |
BEFREE |
FCER1A (rs7549785) and possibly POLR3G (rs7712322) are shown to be associated with peginterferon alfa-2a response in adult patients with chronic hepatitis B.
|
30972912 |
2019 |
|
rs76844316
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the genetic variants of rs76844316 in BTLA influence the susceptibility to severe chronic hepatitis B and might play a protective role against the progression of chronic hepatitis B.
|
29558758 |
2018 |
|
rs7574865
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Validation with all the genetic models revealed that rs7574865 polymorphism of <i>STAT4</i> gene was closely associated with chronic HBV infection (<i>P</i><sub>A</sub><0.01) and chronic hepatitis B (CHB)-related HCC (<i>P</i><sub>A</sub><0.05).
|
31160486 |
2019 |
|
rs7574865
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Recent studies demonstrated that single nucleotide polymorphisms (SNPs) rs2293152 in signal transducer and activator of transcription 3 (STAT3) and rs7574865 in signal transducer and activator of transcription 4 (STAT4) are associated with chronic hepatitis B (CHB)-related HCC in the Chinese population.
|
26745093 |
2015 |